Analysis of ligand target systems:

- Determination of the pharmacophoric groups in ligands

- Screening for binders from mixtures

- Development of new drug candidates

- Less than 0.5 nmol of protein (about 25 micrograms) at 500 MHz

- Screening of complex compound mixtures for bioactivity

- Binding constants by competition experiments

- Binding constants by direct analysis of titration data

- No upper size limit for protein

- Proteins can be integrated into liposomes

- Proteins can be integrated into membranes of intact cells

- Proteins can be coupled to solid phase

- Ligands can be from any class of compounds